Peripheral blood CD34+ cell count as a predictor of adequacy of hematopoietic stem cell collection for autologous transplantation/Recuento de celulas CD34+ en sangre periferica como predictor de adecuada recoleccion de progenitores hematopoyeticos para trasplante autologo/Contagem de celulas CD34+ em sangue periferico como preditor de adequada recoleccao de progenitores hematopoieticos para transplante autologo

• Published in: Iatreia (Medellín, Colombia) Colombia), 2016-10, Vol.29 (4), p.424
• Main Authors: Arango, Marcos, Barco, Gloria, Combariza, Juan F, Jaramillo, Sergio, Estrada, Angela
• Format: Article
• Language: Spanish
• ISSN: 0121-0793

Introduction: In order to carry out an autologous transplantation, hematopoietic stem cells should be mobilized to peripheral blood and later collected by apheresis. The CD34+ cell count is a tool to establish the optimal time to begin the apheresis procedure. Objective: To evaluate the association between peripheral blood CD34+ cell count and the successful collection of hematopoietic stem cells. Materials and methods: A predictive test evaluation study was carried out to establish the usefulness of peripheral blood CD34+ cell count as a predictor of successful stem cell collection in patients that will receive an autologous transplantation. Results: 77 patients were included (median age: 49 years; range: 5-66). The predominant baseline diagnosis was lymphoma (53.2%). The percentage of patients with successful harvest of hematopoietic stem cells was proportional to the number of CD34+ cells in peripheral blood at the end of the mobilization procedure. Weproposethat morethan 15 CD34+ cells/[micro]L must be present in order to achieve an adequate collection of hematopoietic stem cells. Conclusion: Peripheral blood CD34+ cell count is a useful tool to predict the successful collection of hematopoietic stem cells. KEY WORDS Blood Components Removal; Cell Transplantation; Colombia; Hematopoietic Cell Growth Factors; Lymphoma; Multiple Myeloma Introduccion: para llevar a cabo un trasplante autologo se deben movilizar los progenitores hematopoyeticos a la sangre periferica y posteriormente recolectarlos por aferesis. El recuento de celulas CD34+ es una herramienta para determinar el mejor momento para la recoleccion. Objetivo: evaluar la asociacion entre el recuento de celulas CD34+ en sangre periferica y la recoleccion exitosa de progenitores hematopoyeticos. Materiales y metodos: evaluacion de una prueba predictiva para determinar la utilidad del recuento de celulas CD34+ en sangre periferica como predictor del exito de la recoleccion de progenitores hematopoyeticos en pacientes a los que se les va a hacer un trasplante autologo. Resultados: se incluyo a 77 pacientes (mediana de edad: 49 anos; rango: 5-66); el diagnostico predominante fue linfoma (53,2%). El porcentaje de pacientes con recoleccion exitosa de progenitores fue proporcional al numero de celulas CD34+ en sangre periferica al finalizar la movilizacion. Proponemos que se deben tener mas de 15 celulas CD34+/[micro]L en sangre periferica para lograr una adecuada recoleccion de progenitores hematopoyet