Early metabolic response after resistance exercise with blood flow restriction in well-trained men: a metabolomics approach

The present study aimed to compare the early metabolic response between high-load resistance exercise (HL-RE) and low-load resistance exercise with blood flow restriction (LL-BFR). Nine young, well-trained men participated in a randomized crossover design in which each subject completed LL-BFR, HL-R...

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Bibliographic Details
Published in:Applied physiology, nutrition, and metabolism nutrition, and metabolism, 2018-03, Vol.43 (3), p.240-246
Main Authors: Valério, Denis F, Berton, Ricardo, Conceição, Miguel S, Canevarolo, Rafael R, Chacon-Mikahil, Mara Patrícia T, Cavaglieri, Cláudia R, Meirelles, Gabriela V, Zeri, Ana C, Libardi, Cleiton A
Format: Article
Language:English
Subjects:
Blood
Blood flow
entraînement contre résistance
entraînement kaatsu
Exercise
Exercise physiology
Isometric exercise
kaatsu training
Mens health
Metabolism
Metabolites
Metabolomics
métabolisme
métabolites
NMR
Nuclear magnetic resonance
Physiological aspects
Physiological research
resistance training
résonance magnétique nucléaire
Strength training
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Summary:The present study aimed to compare the early metabolic response between high-load resistance exercise (HL-RE) and low-load resistance exercise with blood flow restriction (LL-BFR). Nine young, well-trained men participated in a randomized crossover design in which each subject completed LL-BFR, HL-RE, or condition control (no exercise) with a 1-week interval between them. Blood samples were taken immediately before and 5 min after the exercise sessions. Nuclear magnetic resonance spectroscopy identified and quantified 48 metabolites, 6 of which presented significant changes among the exercise protocols. The HL-RE promoted a higher increase in pyruvate, lactate, and alanine compared with the LL-BFR and the control. HL-RE and LL-BFR promoted a higher increase in succinate compared with the control; however, there was no difference between HL-RE and LL-BFR. Also, while there was no difference in acetoacetate between HL-RE and LL-BFR, a greater decrease was observed in both compared with the control. Finally, LL-BFR promoted a greater decrease in choline compared with the control. In conclusion, this study provides by metabolomics a new insight in metabolic response between LL-BFR and HL-RE by demonstrating a distinct response to some metabolites that are not commonly analyzed.
ISSN:1715-5312
1715-5320
DOI:10.1139/apnm-2017-0471