Mitigating Effect of Nitrates

We studied the effect of radioprotector indralin (B-190) alone or in combination with monizol on BP and HR in rabbits, reduction of blood supply and spleen weight in rats and (CBA x C57B1/6)[F.sub.1] hybrids mice, and on blood loss from a wound on tip of the tail in mice. Being an [[alpha].sub.1]-ad...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2018-07, Vol.165 (3), p.364
Main Authors: Ganshina, T.S, Mirzoyan, R.S, Vasin, M.V, Semenova, L.A, Ushakov, I.B, Koroleva, L.V, Afanasev, R.V
Format: Article
Language:English
Subjects:
Hypertension
Ionizing radiation
Nitrates
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Summary:We studied the effect of radioprotector indralin (B-190) alone or in combination with monizol on BP and HR in rabbits, reduction of blood supply and spleen weight in rats and (CBA x C57B1/6)[F.sub.1] hybrids mice, and on blood loss from a wound on tip of the tail in mice. Being an [[alpha].sub.1]-adrenomimetic, indralin caused hypertensive reaction with the development of bradycardia, reduced blood supply and spleen weight, and sharply reduced blood loss from the wound. Monizol as nitrate reduced BP without affecting HR and reduced blood loss from the wound. Monizol administered prior to indralin eliminated radioprotector-induced hypertensive reaction, reduced bradycardia by more than 2 times, and attenuated the effect of indralin on spleen weight and blood loss from the wound by 1.6-1.8 times. Monizol administered after indralin had no effect on shifts in peripheral blood supply caused by the radioprotector. Key Words: indralin; nitrates; blood pressure; blood supply to the spleen; blood loss
ISSN:0007-4888