Biochemical, Anthropometric and Lifestyle Factors Related with Weight Maintenance after Weight Loss Secondary to a Hypocaloric Mediterranean Diet

Background/Aims: The aim of our study was to evaluate the influence of lifestyle factors and molecular biomarkers on the maintenance of the weight lost after a hypocaloric Mediterranean diet. Design: After 3 months on a diet, patients (n = 335) remained with no controlled diet during 3 years and the...

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Bibliographic Details
Published in:Annals of nutrition and metabolism 2017-01, Vol.71 (3/4), p.217-223
Main Authors: de Luis, Daniel Antonio, Izaola, Olatz, Primo, David, Ovalle, Hilda F., Lopez, Juan Jose, Gomez, Emilia, Ortola, Ana, Aller, Rocio
Format: Article
Language:English
Subjects:
Analysis
Anthropometry
Biochemistry
Biological markers
Biomarkers
Body measurements
Body weight changes
Body weight loss
Dependent variables
Diet
Exercise
Homeostasis
Insulin
Insulin resistance
Leptin
Lifestyles
Maintenance
Mediterranean diet
Obesity
Original Paper
Physical activity
Reducing diets
Regression analysis
Serum levels
Weight control
Weight loss
Weight loss maintenance
Weight reduction
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Summary:Background/Aims: The aim of our study was to evaluate the influence of lifestyle factors and molecular biomarkers on the maintenance of the weight lost after a hypocaloric Mediterranean diet. Design: After 3 months on a diet, patients (n = 335) remained with no controlled diet during 3 years and they were revaluated. Results: Using linear regression, in the group of responders, we detected that a positive weight loss at 3 months, serum levels of leptin at 3 months, and each 30 min per week of physical activity were associated with weight loss maintenance. In the model with reduced weight (RW) as dependent variable, a positive weight loss at 3 months was associated with 2.4% RW (95% CI 1.31–8.11; p = 0.015), each unit of serum leptin levels at 3 months with –0.44% RW (95% CI –0.59 to –0.020; p = 0.007), each basal unit homeostasis model assessment for insulin resistance (HOMA-IR) level with –2.32% (95% CI –13.01 to –0.17; p = 0.040), and each 30 min per week of physical activity with 1.58% RW (95% CI 1.08–2.94; p = 0.020). Conclusion: Obese subjects who are on maintenance weight loss after a dietary intervention appear to have a better initial response during the 3 months intervention, more physical activity at 3 years, and lower basal HOMA-IR and leptin after weight loss than those who regain weight.
ISSN:0250-6807
1421-9697
DOI:10.1159/000484446