Liver stiffness measurement by transient elastography can predict outcome after hepatic resection for hepatitis C virus-induced hepatocellular carcinoma

Objective The aim was to assess the predictive value of liver stiffness (LS) measurement by transient elastography (FibroScan) on the risk of postoperative hepatic decompensation in patients with cirrhosis undergoing hepatectomy for hepatocellular carcinoma (HCC). Patients and methods This prospecti...

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Bibliographic Details
Published in:The Egyptian journal of surgery : official organ of the Egyptian Society of Surgeons = Majallat al-jirāhah al-Misrīyah 2019-04, Vol.38 (2), p.313-318
Main Authors: Hegazy, Osama, Allam, Mahmoud, Sabry, Aliaa, Kohla, Mohamed, Abogharbia, Waleed, Abogabal, Ashraf
Format: Article
Language:English
Subjects:
Analysis
Cancer
Carcinoma
Care and treatment
Comorbidity
Hepatectomy
Hepatitis C virus
Hepatocellular carcinoma
Liver
Medical research
Risk factors
Treatment outcome
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Summary:Objective The aim was to assess the predictive value of liver stiffness (LS) measurement by transient elastography (FibroScan) on the risk of postoperative hepatic decompensation in patients with cirrhosis undergoing hepatectomy for hepatocellular carcinoma (HCC). Patients and methods This prospective study was conducted on 40 adult patients with hepatitis C virus (HCV)-related HCC eligible for hepatic resection between 2015 and 2017. LS was prospectively measured for all patients. Preoperative and postoperative variables (patients' demographics, comorbidities, laboratory, and radiological data) were collected. Results Hepatic insufficiency occurred in 35% of patients (14 patients). Receiver operating characteristic curve analysis of preoperative LS measurement identified a value equal to or higher than 15.4 KPa as the best cutoff value for predicting postoperative hepatic decompensation, with a sensitivity of 100%, specificity 100%, a positive predictive value of 100%, and a negative predictive value of 100%. Conclusion LS measured by transient elastography (FibroScan) is a potentially reliable tool to predict postoperative hepatic decompensation in patients undergoing surgical resection for HCC.
ISSN:1110-1121
1687-7624
DOI:10.4103/ejs.ejs_207_18