Formation of Alcohol Motivation in Monkeys

The effects of environmental factors (flavors, different ethanol concentration, alcoholic deprivation, and food reinforcement) on the formation of alcohol motivation was studied in rhesus macaques (Macaca mulatta, n=6). Motivation for alcohol intake was induced in two stages: initiation (sessions 1-...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2019-08, Vol.167 (4), p.516
Main Authors: Pavlova, L.E, Seredenin, S.B, Kolik, L.G, Lapin, B.A, Chuguev, Yu.P, Shmaliy, A.V, Kovalenko, V.V
Format: Article
Language:English
Subjects:
Alcoholism
Analysis
Drinking of alcoholic beverages
Primates
Online Access:Get full text
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Summary:The effects of environmental factors (flavors, different ethanol concentration, alcoholic deprivation, and food reinforcement) on the formation of alcohol motivation was studied in rhesus macaques (Macaca mulatta, n=6). Motivation for alcohol intake was induced in two stages: initiation (sessions 1-160) and formation of motivation (sessions 161-516). Monkeys preferred multifruit flavor and 4% ethanol solution, while ethanol deprivation did not stimulate alcohol consumption. The pronounced individual differences in the pattern of alcohol motivation were revealed: the intake of 4% ethanol solution ranged from 0.21 [+ or -] 0.03 to 0.43 [+ or -] 0.06 g/kg without food reinforcement and increased from 0.78 [+ or -] 0.03 to 1.22 [+ or -] 0.09 g/kg with food reinforcement. The results suggest that the proposed method is valid and can be used as an experimental model of alcohol dependence in non-human primates. Key Words: rhesus macaques; ethanol; intake; alcohol motivation
ISSN:0007-4888