Effect of Tussilago farfara L. Polysaccharides on the Content of Hematopoietic Stem Cells

Myelotoxicity is a serious side effect of anticancer drugs. The search for drugs that can reduce the hematological complications of chemotherapy through modulation of hematopoietic stem cells is an urgent task of oncopharmacology. In the present study we showed that administration of Tussilago farfa...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020-11, Vol.170 (1), p.171
Main Authors: Dyagel, A. R, Safonova, E. A, Razina, T. G, Gur'ev, A. M, Krylova, S. G, Belousov, M. V, Lopatina, K. A
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Hematopoietic stem cells
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Summary:Myelotoxicity is a serious side effect of anticancer drugs. The search for drugs that can reduce the hematological complications of chemotherapy through modulation of hematopoietic stem cells is an urgent task of oncopharmacology. In the present study we showed that administration of Tussilago farfara L. polysaccharides to C57BL/6 mice treated with cyclophosphamide can increase the number of hematopoietic stem cells (CD117.sup.+34.sup.+) in the bone marrow.
ISSN:0007-4888