Sensitivity of Mycobacterium leprae to Telacebec

The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis The unprecedented potency of Telacebec against M. leprae war...

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Bibliographic Details
Published in:Emerging infectious diseases 2022-03, Vol.28 (3), p.749-751
Main Authors: Lahiri, Ramanuj, Adams, Linda B, Thomas, Sangeeta Susan, Pethe, Kevin
Format: Article
Language:English
Subjects:
Antitubercular agents
Dosage and administration
Drug therapy
Health aspects
Imidazoles
Leprosy
Mycobacterium leprae
Piperidines
Pyridines
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Summary:The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis The unprecedented potency of Telacebec against M. leprae warrants further validation in clinical trials.
ISSN:1080-6040
1080-6059
DOI:10.3201/2803.210394