Effect of Metformin on Glycemic Control Regarding Carriers of the SLC22A1/ OCT1

Purpose: Differences in metformin effect on glycemic control in type 2 Diabetes (T2D) have been associated with diet, obesity, years since T2D diagnosis and genetic factors, such as the Met408Val (rs628031) SLC22A1/OCT1 gene polymorphism. This study aimed to analyze the effect of metformin and diet...

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Published in:Diabetes, metabolic syndrome and obesity metabolic syndrome and obesity, 2022-06, Vol.15, p.1771
Main Authors: Rangel-Rios, Ernesto, Martinez, J Fausto Bustamante, Bernal-Perez, J Antonio, Barron-Cabrera, Elisa, Martfnez-Lopez, Erika, Zepeda-Carrillo, A. Eloy, Ramos-Lopez, Omar, Torres-Valadez, Rafael, Velasco-Gonzalez, E. Luisa
Format: Article
Language:English
Subjects:
Analysis
Diabetes therapy
Diet therapy
Genetic aspects
Genetic polymorphisms
Glibenclamide
Glycosylated hemoglobin
Metformin
Type 2 diabetes
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Summary:Purpose: Differences in metformin effect on glycemic control in type 2 Diabetes (T2D) have been associated with diet, obesity, years since T2D diagnosis and genetic factors, such as the Met408Val (rs628031) SLC22A1/OCT1 gene polymorphism. This study aimed to analyze the effect of metformin and diet on glycemic control and its association with the Met408Val polymorphism in patients with T2D from western Mexico. Patients and Methods: A total of 240 T2D adult patients were enrolled in this cross-sectional study. Anti-hyperglycemic therapy, dietary intake, body composition and glycemic profile were recorded and the determination of genotypes of SLC22A1/OCT1 gene (rs628031) was performed using an allelic discrimination assay. Results: The type of metformin therapy was 47% monotherapy, 45% dual therapy (metformin+glibenclamide or metformin+insulin) and 8% triple therapy (metformin+glibenclamide+insulin). Individuals with metformin monotherapy had a higher glycemic control frequency (%HbA1c
ISSN:1178-7007
1178-7007