Bryostatin Enhancement of Memory in Hermissenda

Bryostatin, a potent agonist of protein kinase C (PKC), when administered to Hermissenda was found to affect acquisition of an associative learning paradigm. Low bryostatin concentrations (0.1 to 0.5 ng/ml) enhanced memory acquisition, while concentrations higher than 1.0 ng/ml down-regulated the pa...

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Bibliographic Details
Published in:The Biological bulletin (Lancaster) 2006-06, Vol.210 (3), p.201-214
Main Authors: Kuzirian, A. M., Epstein, H. T., C. J. Gagliardi, Nelson, T. J., M. Sakakibara, Taylor, C., A. B. Scioletti, Alkon, D. L.
Format: Article
Language:English
Subjects:
Animal cognition
Animal memory
Animal training
Animals
Associative learning
Behavior
Behavioral neuroscience
Bryostatins
Conditioning, Classical
Consolidation
Depolarization
Eye - cytology
Eye - metabolism
Hermissenda
Hermissenda - physiology
Immunohistochemistry
Indoles - pharmacology
Learning - drug effects
Macrolides - pharmacology
Maleimides - pharmacology
Marine
Marine Invertebrate Models of Learning and Memory
Memory
Memory - drug effects
Memory recall
Nudibranchiata
Nudibranchs
Photoreceptors
Protein Kinase C - antagonists & inhibitors
Protein Kinase C - metabolism
Protein synthesis
Psychological aspects
Sea water
Training
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Summary:Bryostatin, a potent agonist of protein kinase C (PKC), when administered to Hermissenda was found to affect acquisition of an associative learning paradigm. Low bryostatin concentrations (0.1 to 0.5 ng/ml) enhanced memory acquisition, while concentrations higher than 1.0 ng/ml down-regulated the pathway and no recall of the associative training was exhibited. The extent of enhancement depended upon the conditioning regime used and the memory stage normally fostered by that regime. The effects of two training events (TEs) with paired conditioned and unconditioned stimuli, which standardly evoked only short-term memory (STM) lasting 7 min, were-when bryostatin was added concurrently-enhanced to a long-term memory (LTM) that lasted about 20 h. The effects of both 4- and 6-paired TEs (which by themselves did not generate LTM), were also enhanced by bryostatin to induce a consolidated memory (CM) that lasted at least 5 days. The standard positive 9-TE regime typically produced a CM lasting at least 6 days. Low concentrations of bryostatin (
ISSN:0006-3185
1939-8697
DOI:10.2307/4134558