Ivermectin: a potent new antiparasitic agent [Nematode and arthropod parasites]

Ivermectin is the 22,23-dihydro derivative of avermectin B$_{1}$, a macrocyclic lactone produced by an actinomycete, Streptomyces avermitilis. It is active at extremely low dosage against a wide variety of nematode and arthropod parasites, apparently by virtue of its action on the mediation of neuro...

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Published in:Science (American Association for the Advancement of Science) 1983-08, Vol.221 (4613), p.823-828
Main Authors: CAMPBELL, W. C, FISHER, M. H, STAPLEY, E. O, ALBERS-SCHONBERG, G, JACOB, T. A
Format: Article
Language:English
Subjects:
Animals
Anthelmintics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Antiparasitics
Arthropods
Arthropods - drug effects
Biological and medical sciences
Control
Dogs
Dosage
Helminths
Humans
Insecticides - therapeutic use
Ivermectin
Lactones - metabolism
Lactones - pharmacology
Lactones - therapeutic use
Medical sciences
Microbiological research
Nematode Infections - drug therapy
Nematodes
Parasite hosts
Parasites
Parasitism
Parasitological research
Pharmacology. Drug treatments
Streptomyces - physiology
Structure-Activity Relationship
Swine
Synaptic Transmission - drug effects
Ticks
Veterinary medicine
Worms, Intestinal and parasitic
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description Ivermectin is the 22,23-dihydro derivative of avermectin B$_{1}$, a macrocyclic lactone produced by an actinomycete, Streptomyces avermitilis. It is active at extremely low dosage against a wide variety of nematode and arthropod parasites, apparently by virtue of its action on the mediation of neurotransmission by γ-aminobutyric acid. It is now in commercial use in various countries for the treatment and control of parasites in cattle, horses, and sheep, and is expected to become available for use in swine and dogs. Since studies with the drug in man are in a preliminary stage, it is not yet known whether ivermectin will be useful in human medicine.
doi_str_mv 10.1126/science.6308762
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identifier ISSN: 0036-8075
ispartof Science (American Association for the Advancement of Science), 1983-08, Vol.221 (4613), p.823-828
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1095-9203
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source American Association for the Advancement of Science
subjects Animals
Anthelmintics
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Antiparasitics
Arthropods
Arthropods - drug effects
Biological and medical sciences
Control
Dogs
Dosage
Helminths
Humans
Insecticides - therapeutic use
Ivermectin
Lactones - metabolism
Lactones - pharmacology
Lactones - therapeutic use
Medical sciences
Microbiological research
Nematode Infections - drug therapy
Nematodes
Parasite hosts
Parasites
Parasitism
Parasitological research
Pharmacology. Drug treatments
Streptomyces - physiology
Structure-Activity Relationship
Swine
Synaptic Transmission - drug effects
Ticks
Veterinary medicine
Worms, Intestinal and parasitic
title Ivermectin: a potent new antiparasitic agent [Nematode and arthropod parasites]
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