A G protein couples serotonin and GABAB receptors to the same channels in hippocampus

Both serotonin and the selective gamma-aminobutyric acidB (GABAB) agonist, baclofen, increase potassium (K+) conductance in hippocampal pyramidal cells. Although these agonists act on separate receptors, the potassium currents evoked by the agonists are not additive, indicating that the two receptor...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1986-12, Vol.234 (4781), p.1261-1265
Main Authors: ANDRADE, R, MALENKA, R. C, NICOLL, R. A
Format: Article
Language:English
Subjects:
Animals
Baclofen - pharmacology
Biological and medical sciences
Calcium - metabolism
Cell physiology
Cell receptors
Fundamental and applied biological sciences. Psychology
GTP-Binding Proteins - pharmacology
Guanosine 5'-O-(3-Thiotriphosphate)
Guanosine Diphosphate - analogs & derivatives
Guanosine Diphosphate - pharmacology
Guanosine Triphosphate - analogs & derivatives
Guanosine Triphosphate - pharmacology
Hippocampus (Brain)
Hippocampus - drug effects
Innovations
Ion Channels - metabolism
Molecular and cellular biology
Neurotransmission
Neurotransmitter receptors
Phorbol 12,13-Dibutyrate
Phorbol Esters - pharmacology
Potassium - metabolism
Protein research
Rats
Receptors, GABA-A - drug effects
Receptors, GABA-A - metabolism
Receptors, Serotonin - drug effects
Receptors, Serotonin - metabolism
Serotonin - pharmacology
Spiperone - pharmacology
Thionucleotides - pharmacology
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Summary:Both serotonin and the selective gamma-aminobutyric acidB (GABAB) agonist, baclofen, increase potassium (K+) conductance in hippocampal pyramidal cells. Although these agonists act on separate receptors, the potassium currents evoked by the agonists are not additive, indicating that the two receptors share the same potassium channels. Experiments with hydrolysis-resistant guanosine triphosphate (GTP) and guanosine diphosphate analogs and pertussis toxin indicate that the opening of the potassium channels by serotonin and GABAB receptors involves a pertussis toxin-sensitive GTP-binding (G) protein, which may directly couple the two receptors to the potassium channel.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.2430334