Evidence for a "Founder Effect" among HIV-infected injection drug users

We have previously reported a HIV-1 subtype A infection in a community of injection drug users (IDUs) in Karachi, Pakistan. We now show that this infection among the IDUs may have originated from a single source. Phylogenetic analysis was performed of partial gag sequences, generated using PCR, from...

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Published in:BMC infectious diseases 2010-01, Vol.10, p.7
Main Authors: Rai, Mohammad A, Nerurkar, Vivek R, Khoja, Suhail, Khan, Saeed, Yanagihara, Richard, Rehman, Arish, Kazmi, Shahana U, Ali, Syed H
Format: Article
Language:English
Subjects:
Demographic aspects
Disease transmission
Distribution
Health aspects
HIV infection
Intravenous drug abuse
Migrant labor
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container_title BMC infectious diseases
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creator Rai, Mohammad A
Nerurkar, Vivek R
Khoja, Suhail
Khan, Saeed
Yanagihara, Richard
Rehman, Arish
Kazmi, Shahana U
Ali, Syed H
description We have previously reported a HIV-1 subtype A infection in a community of injection drug users (IDUs) in Karachi, Pakistan. We now show that this infection among the IDUs may have originated from a single source. Phylogenetic analysis was performed of partial gag sequences, generated using PCR, from 26 HIV-positive IDU samples. Our results showed formation of a tight monophyletic group with an intra-sequence identity of [less than] 98% indicating a "founder effect". Our data indicate that the HIV-1 epidemic in this community of IDUs may have been transmitted by an HIV positive overseas contract worker who admitted to having contact with commercial sex workers during stay abroad. Specific measures need to implemented to control transmission of HIV infection in Pakistan through infected migrant workers.
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subjects Demographic aspects
Disease transmission
Distribution
Health aspects
HIV infection
Intravenous drug abuse
Migrant labor
title Evidence for a "Founder Effect" among HIV-infected injection drug users
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