Social impairments in chromosome 22q11.2 deletion syndrome

High prevalence of autism spectrum disorders (ASD) has been reported in 22q11.2DS, although this has been based solely on parent report measures. This study describes the presence of ASD using a procedure more similar to that used in clinical practice by incorporating history (Social Communication Q...

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Bibliographic Details
Published in:Journal of autism and developmental disorders 2014-04, Vol.44 (4), p.739
Main Authors: Angkustsiri, Kathleen, Goodlin-Jones, Beth, Deprey, Lesley, Brahmbhatt, Khyati, Harris, Susan, Simon, Tony J
Format: Article
Language:English
Subjects:
Care and treatment
Development and progression
DiGeorge syndrome
Patient outcomes
Risk factors
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Summary:High prevalence of autism spectrum disorders (ASD) has been reported in 22q11.2DS, although this has been based solely on parent report measures. This study describes the presence of ASD using a procedure more similar to that used in clinical practice by incorporating history (Social Communication Questionnaire) AND a standardized observation measure (Autism Diagnostic Observation Schedule) and suggests that ASD is not as common as previously reported in 22q11.2DS. Differences in methodology, along with comorbid conditions such as anxiety, likely contribute to false elevations in ASD prevalence and information from multiple sources should be included in the evaluation of ASD.
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-013-1920-x