Sensitivity and specificity of the World Health Organization dengue classification schemes for severe dengue assessment in children in Rio de Janeiro

PrincipalFindings: Using the traditional scheme, 28.5% of patients could not be assigned to any category, while the revised scheme categorized all patients. Intensive therapeutic interventions were used as the reference standard to evaluate the ability of both the traditional and revised schemes to...

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Bibliographic Details
Published in:PLoS ONE 2014, Vol.9 (4)
Main Authors: Macedo, Gleicy A, Gonin, Michelle Luiza C, Pone, Sheila M, Cruz, Oswaldo G, Nobre, Flavio F, Brasil, Patricia
Format: Report
Language:English
Subjects:
Children
Control
Dengue
Distribution
Health aspects
Public health
Online Access:Get full text
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Summary:PrincipalFindings: Using the traditional scheme, 28.5% of patients could not be assigned to any category, while the revised scheme categorized all patients. Intensive therapeutic interventions were used as the reference standard to evaluate the ability of both the traditional and revised schemes to detect severe dengue cases. Analyses of the classified cases (n = 183) demonstrated that the revised scheme had better sensitivity (86.8%, P < 0.001), while the traditional scheme had better specificity (93.4%, P < 0.001) for the detection of severe forms of dengue.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0096314