Enterovirus71

Hand, Foot and Mouth Disease (HFMD) is a self-limiting viral disease that mainly affects infants and children. In contrast with other HFMD causing enteroviruses, Enterovirus71 (EV71) has commonly been associated with severe clinical manifestation leading to death. Currently, due to a lack in underst...

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Bibliographic Details
Published in:PloS one 2014-07, Vol.9 (7)
Main Authors: Lui, Yan Long Edmund, Tan, Tuan Lin, Woo, Wee Hong, Timms, Peter, Hafner, Louise Marie, Tan, Kian Hwa, Tan, Eng Lee
Format: Article
Language:English
Subjects:
Analysis
Biosynthesis
Colorectal cancer
Coxsackievirus infections
Health aspects
MicroRNA
Virus diseases
Online Access:Get full text
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Summary:Hand, Foot and Mouth Disease (HFMD) is a self-limiting viral disease that mainly affects infants and children. In contrast with other HFMD causing enteroviruses, Enterovirus71 (EV71) has commonly been associated with severe clinical manifestation leading to death. Currently, due to a lack in understanding of EV71 pathogenesis, there is no antiviral therapeutics for the treatment of HFMD patients. Therefore the need to better understand the mechanism of EV71 pathogenesis is warranted. We have previously reported a human colorectal adenocarcinoma cell line (HT29) based model to study the pathogenesis of EV71. Using this system, we showed that knockdown of DGCR8, an essential cofactor for microRNAs biogenesis resulted in a reduction of EV71 replication. We also demonstrated that there are miRNAs changes during EV71 pathogenesis and EV71 utilise host miRNAs to attenuate antiviral pathways during infection. Together, data from this study provide critical information on the role of miRNAs during EV71 infection.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0102997