A Capsaicin

Persistent pain after inguinal herniorrhaphy is a disabling condition with a lack of evidence-based pharmacological treatment options. This randomized placebo-controlled trial investigated the efficacy of a capsaicin 8% cutaneous patch in the treatment of severe persistent inguinal postherniorrhaphy...

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Bibliographic Details
Published in:PloS one 2014-10, Vol.9 (10)
Main Authors: Bischoff, Joakim M, Ringsted, Thomas K, Petersen, Marian, Sommer, Claudia, Ãçeyler, Nurcan, Werner, Mads U
Format: Article
Language:English
Subjects:
Capsaicin
Clinical trials
Evidence-based medicine
Pain management
Phenols (Class of compounds)
Skin
Sleep
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Summary:Persistent pain after inguinal herniorrhaphy is a disabling condition with a lack of evidence-based pharmacological treatment options. This randomized placebo-controlled trial investigated the efficacy of a capsaicin 8% cutaneous patch in the treatment of severe persistent inguinal postherniorrhaphy pain. Forty-six patients with persistent inguinal postherniorrhaphy pain were randomized to receive either a capsaicin 8% patch or a placebo patch. Pain intensity (Numerical Rating Scale [NRS 0-10]) was evaluated under standardized conditions (at rest, during movement, and during pressure) at baseline and at 1, 2 and 3 months after patch application. Skin punch biopsies for intraepidermal nerve fiber density (IENFD) measurements were taken at baseline and 1 month after patch application. Quantitative sensory testing was performed at baseline and at 1, 2, and 3 months after patch application. The primary outcome was comparisons of summed pain intensity differences (SPIDs) between capsaicin and placebo treatments at 1, 2 and 3 months after patch application (significance level P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0109144