Association Study between the FTCDNL1

Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs760537...

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Bibliographic Details
Published in:PloS one 2015-10, Vol.10 (10), p.e0140549
Main Authors: Lu, Hsing-Fang, Hung, Kuo-Sheng, Hsu, Yu-Wen, Tai, Yu-Ting, Huang, Lin-Shan, Wang, Yu-Jia, Wong, Henry Sung-Ching, Hsu, Yi-Hsiang, Chang, Wei-Chiao
Format: Article
Language:English
Subjects:
Disease susceptibility
Genes
Genetic aspects
Genetic polymorphisms
Medical research
Osteoporosis
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Summary:Osteoporosis is a systemic skeletal disease characterized by a decreased bone mineral density that results in an increased risk of fragility fractures. Previous studies indicated that genetic factors are involved in the pathogenesis of osteoporosis. Polymorphisms of the FONG (FTCDNL1) gene (rs7605378) were reported to be associated with the risk of osteoporosis in a Japanese population. To assess whether polymorphisms of the FTCDNL1 gene contribute to the susceptibility and severity of osteoporosis in a Taiwanese population, 326 osteoporosis patients and 595 controls of a Taiwanese population were included in this study. Our results indicated that rs10203122 was significantly associated with osteoporosis susceptibility among female. Our findings provide evidence that rs10203122 in FTCDNL1 is associated with a susceptibility to osteoporosis.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0140549