Prevalence of Antibodies against Avian Influenza A

Between 2003 and 2005, highly pathogenic avian influenza A (H5N1) viruses caused large scale outbreaks in poultry in the Ho Chi Minh City area in Vietnam. We studied the prevalence of antibodies against H5N1 in poultry workers and cullers who were active in the program in Ho Chi Minh City in 2004 an...

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Bibliographic Details
Published in:PloS one 2009-11, Vol.4 (11), p.e7948
Main Authors: Schultsz, Constance, Van Dung, Nguyen, Hai, Le Thanh, Quang Ha, Do, Peiris, J. S. Malik, Lim, Wilina, Garcia, Jean-Michel, Dac Tho, Nguyen, Thi Hoang Lan, Nguyen, Huu Tho, Huynh, Xuan Thao, Phan, van Doorn, H. Rogier, Vinh Chau, Nguyen Van, Farrar, Jeremy, de Jong, Menno D
Format: Article
Language:English
Subjects:
Antibodies
Avian influenza
Avian influenza viruses
Poultry industry
Workers
Online Access:Get full text
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Summary:Between 2003 and 2005, highly pathogenic avian influenza A (H5N1) viruses caused large scale outbreaks in poultry in the Ho Chi Minh City area in Vietnam. We studied the prevalence of antibodies against H5N1 in poultry workers and cullers who were active in the program in Ho Chi Minh City in 2004 and 2005. Single sera from 500 poultry workers and poultry cullers exposed to infected birds were tested for antibodies to avian influenza H5N1, using microneutralization assays and hemagglutination inhibition assay with horse blood. All sera tested negative using microneutralization tests. Three samples showed a 1:80 titer in the hemagglutination inhibition assay. This study provides additional support for the low transmissibility of clade 1 H5N1 to humans, but limited transmission to highly exposed persons cannot be excluded given the presence of low antibody titers in some individuals.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0007948