Cerebrospinal Fluid Melanin-Concentrating Hormone

Ancillary to decline in cognitive abilities, patients with Alzheimer's disease (AD) frequently suffer from behavioural and psychological symptoms of dementia (BPSD). Hypothalamic polypeptides such as melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) are promoters of sleep-...

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Bibliographic Details
Published in:PloS one 2013-05, Vol.8 (5), p.e63136
Main Authors: Schmidt, Frank M, Kratzsch, Juergen, Gertz, Hermann-Josef, Tittmann, Mandy, Jahn, Ina, Pietsch, Uta-Carolin, Kaisers, Udo X, Thiery, Joachim, Hegerl, Ulrich, Schönknecht, Peter
Format: Article
Language:English
Subjects:
Advertising executives
Alzheimer's disease
Biopolymers
Brain
Energy law
Hormones
Sleep
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Summary:Ancillary to decline in cognitive abilities, patients with Alzheimer's disease (AD) frequently suffer from behavioural and psychological symptoms of dementia (BPSD). Hypothalamic polypeptides such as melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) are promoters of sleep-wake regulation and energy homeostasis and are found to impact on cognitive performance. To investigate the role of MCH and HCRT-1 in AD, cerebrospinal fluid (CSF) levels were measured in 33 patients with AD and 33 healthy subjects (HS) using a fluorescence immunoassay (FIA). A significant main effect of diagnosis (F(1,62) = 8.490, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0063136