Chemopreventive Evaluation of a Schiff Base Derived Copper

• Published in: PloS one 2014-03, Vol.9 (3), p.e91246
• Main Authors: Hajrezaie, Maryam, Hassandarvish, Pouya, Moghadamtousi, Soheil Zorofchian, Gwaram, Nura Suleiman, Golbabapour, Shahram, NajiHussien, Abdrabuh, Almagrami, Amel Abdullah, Zahedifard, Maryam, Rouhollahi, Elham, Karimian, Hamed, Fani, Somaye, Kamalidehghan, Behnam, Majid, Nazia Abdul, Ali, Hapipah Mohd, Abdulla, Mahmood Ameen
• Format: Article
• Language: English
• Subjects: Cancer prevention; Chemotherapy; Colorectal cancer; Copper compounds; Immunohistochemistry; Schiff bases
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0091246

Based on the potential of Schiff base compounds to act as sources for the development of cancer chemotherapeutic agents, this in vivo study was performed to investigate the inhibitory properties of the synthetic Schiff base compound Cu(BrHAP).sub.2 on colonic aberrant crypt foci (ACF). This study involved five groups of male rats. The negative control group was injected with normal saline once a week for 2 weeks and fed 10% Tween 20 for 10 weeks, the cancer control group was subcutaneously injected with 15 mg/kg azoxymethane once per week for two consecutive weeks, the positive control group was injected with 15 mg/kg azoxymethane once per week for two consecutive weeks and 35 mg/kg 5-fluorouracil (injected intra-peritoneally) for 4 weeks, and the experimental groups were first injected with 15 mg/kg azoxymethane once per week for two consecutive weeks and then fed 2.5 or 5 mg/kg of the Schiff base compound once a day for 10 weeks. Application of the Schiff base compound suppressed total colonic ACF formation by up to 72% to 74% (P