Increased Risk of Serious Non-AIDS-Related Events in HIV-Infected Subjects on Antiretroviral Therapy Associated with a Low CD4/CD8 Ratio

• Published in: PLoS ONE 2014, Vol.9 (1), p.e85798
• Main Authors: Serrano-Villar, Sergio, Pérez-Elías, María Jesús, Dronda, Fernando, Casado, José Luis, Moreno, Ana, Royuela, Ana, Pérez-Molina, José Antonio, Sainz, Talia, Navas, Enrique, Hermida, José Manuel, Quereda, Carmen, Moreno, Santiago
• Format: Report
• Language: English
• Subjects: AIDS (Disease); Antiretroviral agents; Cardiovascular diseases; Chronic kidney failure; Health aspects; Highly active antiretroviral therapy; HIV; HIV patients; Mortality
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0085798

A low CD4/CD8 ratio has been identified in the general population as a hallmark of inmmunosenescence and a surrogate of all-cause mortality. We aimed to investigate in treated HIV-infected individuals the relationship between the CD4/CD8 ratio and serious non-AIDS events. Case-control study within a prospective hospital-based cohort of HIV-infected subjects during at least one year of ART-mediated viral suppression. Cases were patients with serious non-AIDS events (non-AIDS malignancies, cardiovascular disease, and end-stage kidney disease), and controls individuals who did not developed non-AIDS events during follow-up. Data were analyzed using ROC analysis and multivariate logistic regression. Conditional logistic regression was performed in 200 cases/controls matched by age, sex, nadir CD4 and proximal CD4 counts. We analyzed 407 subjects (109 cases, 298 controls). The CD4/CD8 ratio was lower in cases (0.44 vs. 0.70, P