Prognostic Impact of del

Most sporadic colorectal cancer (sCRC) deaths are caused by metastatic dissemination of the primary tumor. New advances in genetic profiling of sCRC suggest that the primary tumor may contain a cell population with metastatic potential. Here we compare the cytogenetic profile of primary tumors from...

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Bibliographic Details
Published in:PloS one 2012-08, Vol.7 (8), p.e42683
Main Authors: González-González, María, Muñoz-Bellvis, Luís, Mackintosh, Carlos, Fontanillo, Celia, Gutiérrez, M. Laura, Abad, M. Mar, Bengoechea, Oscar, Teodosio, Cristina, Fonseca, Emilio, Fuentes, Manuel, De Las Rivas, Javier, Orfao, Alberto, María Sayagués, José
Format: Article
Language:English
Subjects:
Analysis
Cancer metastasis
Chromosomes
Colorectal cancer
Liver cancer
Medical research
Online Access:Get full text
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Summary:Most sporadic colorectal cancer (sCRC) deaths are caused by metastatic dissemination of the primary tumor. New advances in genetic profiling of sCRC suggest that the primary tumor may contain a cell population with metastatic potential. Here we compare the cytogenetic profile of primary tumors from liver metastatic versus non-metastatic sCRC. We prospectively analyzed the frequency of numerical/structural abnormalities of chromosomes 1, 7, 8, 13, 14, 17, 18, 20, and 22 by iFISH in 58 sCRC patients: thirty-one non-metastatic (54%) vs. 27 metastatic (46%) disease. From a total of 18 probes, significant differences emerged only for the 17p11.2 and 22q11.2 chromosomal regions. Patients with liver metastatic sCRC showed an increased frequency of del(17p11.2) (10% vs. 67%;p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0042683