Prevalence of peripheral artery disease

• Published in: PloS one 2017-10, Vol.12 (10), p.e0186220
• Main Authors: Cornejo del Río, V, Mostaza, J, Lahoz, C, Sánchez-Arroyo, V, Sabín, C, López, S, Patrón, P, Fernández-García, P, Fernández-Puntero, B, Vicent, D, Montesano-Sánchez, L, García-Iglesias, F, González-Alegre, T, Estirado, E, Laguna, F, de Burgos-Lunar, C, Gómez-Campelo, P, Abanades-Herranz, J. C, de Miguel-Yanes, J. M, Salinero-Fort, M. A
• Format: Article
• Language: English
• Subjects: Complications and side effects; Development and progression; Diagnosis; Health screening; Peripheral vascular diseases; Risk factors; Type 2 diabetes
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0186220

To describe the prevalence of Peripheral Artery Disease (PAD) in a random population sample and to evaluate its relationship with Mediterranean diet and with other potential cardiovascular risk factors such as serum uric acid and pulse pressure in individuals ranged 45 to 74 years. Cross-sectional analysis of 1568 subjects (mean age 6.5 years, 43% males), randomly selected from the population. A fasting blood sample was obtained to determine glucose, lipids, and HbA1C levels. An oral glucose tolerance test was performed in non-diabetic subjects. PAD was evaluated by ankle-brachial index and/or having a prior diagnosis. PAD prevalence was 3.81% (95% CI, 2.97-4.87) for all participants. In men, PAD prevalence was significantly higher than in women [5.17% (95% CI, 3.74-7.11) vs. 2.78% (95% CI, 1.89-4.07); p = 0.014]. Our results show the existence of a low prevalence of peripheral artery disease in a population aged 45-74 years. Serum uric acid, pulse pressure and heart rate >90 bpm were strongly associated with peripheral artery disease. The direct association between Mediterranean diet and peripheral artery disease that we have found should be evaluated through a follow-up study under clinical practice conditions.