Central Projection of Pain Arising from Delayed Onset Muscle Soreness

Delayed onset muscle soreness (DOMS) is a subacute pain state arising 24-48 hours after a bout of unaccustomed eccentric muscle contractions. Functional magnetic resonance imaging (fMRI) was used to examine the patterns of cortical activation arising during DOMS-related pain in the quadriceps muscle...

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Bibliographic Details
Published in:PloS one 2012-10, Vol.7 (10), p.e47230
Main Authors: Zimmermann, Katharina, Leidl, Caroline, Kaschka, Miriam, Carr, Richard W, Terekhin, Pavel, Handwerker, Hermann O, Forster, Clemens
Format: Article
Language:English
Subjects:
Brain
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Summary:Delayed onset muscle soreness (DOMS) is a subacute pain state arising 24-48 hours after a bout of unaccustomed eccentric muscle contractions. Functional magnetic resonance imaging (fMRI) was used to examine the patterns of cortical activation arising during DOMS-related pain in the quadriceps muscle of healthy volunteers evoked by either voluntary contraction or physical stimulation. The painful movement or physical stimulation of the DOMS-affected thigh disclosed widespread activation in the primary somatosensory and motor (S1, M1) cortices, stretching far beyond the corresponding areas somatotopically related to contraction or physical stimulation of the thigh; activation also included a large area within the cingulate cortex encompassing posteroanterior regions and the cingulate motor area. Pain-related activations were also found in premotor (M2) areas, bilateral in the insular cortex and the thalamic nuclei. In contrast, movement of a DOMS-affected limb led also to activation in the ipsilateral anterior cerebellum, while DOMS-related pain evoked by physical stimulation devoid of limb movement did not.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0047230