Homeostatic model assessment of adiponectin

• Published in: PloS one 2019-03, Vol.14 (3), p.e0214081
• Main Authors: da Silva, Cleliani de Cassia, Zambon, Mariana Porto, Vasques, Ana Carolina Junqueira, Camilo, Daniella Fernandes, De Bernardi Rodrigues, Ana Maria, Antonio, Maria Ângela Reis de Góes Monteiro, Dâmaso, Ana Raimunda, Tufik, Sergio, de Mello, Marco Tulio, Campos, Raquel Munhoz da Silveira, Geloneze, Bruno
• Format: Article
• Language: English
• Subjects: Analysis; Glucose; Insulin resistance; Pediatrics; Regression analysis; Type 2 diabetes; Youth
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0214081

Studies on adults have reported inverse association between the homeostatic model assessment (HOMA) of adiponectin (HOMA-Adiponectin) and the insulin resistance assessed by the glucose clamp technique. To our knowledge, in the pediatric population this association has not been previously investigated. To evaluate the association between the HOMA-Adiponectin and the insulin resistance assessed by the glucose clamp technique in adolescents, and to compare the accuracy of HOMA-Adiponectin and HOMA-insulin resistance (HOMA-IR) for identifying insulin resistance. This was a cross-sectional study of 56 adolescents (aged 10-18 years). Insulin resistance was assessed using the HOMA-IR, HOMA-Adiponectin and the hyperglycaemic clamp technique. The clamp-derived insulin sensitivity index, HOMA-Adiponectin, and HOMA-IR were log-transformed to get closer to a normal distribution before analysis. In the multivariable linear regression analysis controlling for sex and Tanner stage, HOMA-Adiponectin was inversely associated with the clamp-derived insulin sensitivity index (unstandardized coefficient [B] = -0.441; P < 0.001). After additional adjustment for waist circumference-to-height ratio, this association remained significant (B = -0.349; P = < 0.001). Similar results were observed when HOMA-IR replaced HOMA-Adiponectin in the model (B = -1.049 and B = -0.968 after additional adjustment for waist circumference-to-height ratio); all P < 0.001. The area under the receiver operating characteristic curve for predicting insulin resistance was 0.712 (P = 0.02) for HOMA-Adiponectin and 0.859 (P < 0.0001) HOMA-IR. The HOMA-Adiponectin was independently associated with insulin resistance and exhibited a good discriminatory power for predicting it. However, it did not show superiority over HOMA-IR in the diagnostic accuracy.