Genome-wide association study and scan for signatures of selection point to candidate genes for body temperature maintenance under the cold stress in Siberian cattle populations

We detected a single candidate region on cattle chromosome (BTA)15 overlapping between the GWAS results and the results of scans for selective sweeps. This region contains two genes, MSANTD4 and GRIA4. Both genes are functional candidates to contribute to the cold-stress resistance phenotype, due to...

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Bibliographic Details
Published in:BMC Genetics 2019, Vol.20 (Suppl 1)
Main Authors: Igoshin, Alexander V, Yurchenko, Andrey A, Belonogova, Nadezhda M, Petrovsky, Dmitry V, Aitnazarov, Ruslan B, Soloshenko, Vladimir A, Yudin, Nikolay S, Larkin, Denis M
Format: Report
Language:English
Subjects:
Analysis
Beef cattle
Cattle
Climate
DNA
DNA microarrays
Genes
Genetic aspects
Genetic polymorphisms
Genetics
Genome-wide association studies
Genomes
Genomics
Livestock
Novels
Single nucleotide polymorphisms
Temperature effects
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Summary:We detected a single candidate region on cattle chromosome (BTA)15 overlapping between the GWAS results and the results of scans for selective sweeps. This region contains two genes, MSANTD4 and GRIA4. Both genes are functional candidates to contribute to the cold-stress resistance phenotype, due to their indirect involvement in the cold shock response (MSANTD4) and body thermoregulation (GRIA4). Our results point to a novel region on BTA15 which is a candidate region associated with the body temperature maintenance phenotype in Siberian cattle. The results of our research and the follow up studies might be used for the development of cattle breeds better adapted to cold climates of the Russian Federation and other Northern countries with similar climates.
ISSN:1471-2156
1471-2156
DOI:10.1186/s12863-019-0725-0