Glutathione peroxidase

Oxidative stress is suggested to be the crucial factor in diabetes mellitus type 2 (DM2) pathogenesis and in the development of diabetic complications. Patients with DM2 may be more susceptible to infections due to hyperglycaemia-induced virulence of various microorganisms. Several studies pointed t...

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Bibliographic Details
Published in:PloS one 2020-03, Vol.15 (3), p.e0230374
Main Authors: Dworzanski, Jakub, Strycharz-Dudziak, Malgorzata, Kliszczewska, Ewa, Kielczykowska, Malgorzata, Dworzanska, Anna, Drop, Bartlomiej, Polz-Dacewicz, Malgorzata
Format: Article
Language:English
Subjects:
Analysis
Antioxidants (Nutrients)
Care and treatment
Complications and side effects
Diabetes mellitus
Diabetics
Disease susceptibility
DNA
Enzymes
Epstein-Barr virus
Hyperglycemia
Infection
Microorganisms
Obesity
Oxidative stress
Peroxidase
Risk factors
Superoxides
Thiols
Virulence (Microbiology)
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Summary:Oxidative stress is suggested to be the crucial factor in diabetes mellitus type 2 (DM2) pathogenesis and in the development of diabetic complications. Patients with DM2 may be more susceptible to infections due to hyperglycaemia-induced virulence of various microorganisms. Several studies pointed that Epstein-Barr virus (EBV) infection is associated with reactive oxygen species (ROS) production and/or activation of signalling pathways connected with ROS. The present study analyzed serum activity of glutathione peroxidase (GPx) and superoxide dismutase (SOD) in DM2 patients with and without EBV infection. Blood and saliva were collected from 120 patients with DM2. EBV DNA was detected in the saliva using nested-PCR technique. Spectrophotometric methods were implemented to determine serum GPx and SOD activity with the use of diagnostic kits produced by Randox Laboratories. GPx and SOD activity was decreased in diabetic patients, with the lowest values in DM2 EBV-positive patients. There was correlation between GPx and SOD activity-with increased value of GPx, SOD activity was also rised. In patients with DM2 history longer than 10 years as well as in DM2 patients with obesity, antioxidant enzymes activity was decreased. Determination of examined parameters may be useful in diabetic patients with EBV infection and could be important prognostic factor.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0230374