Prevalence of Blastocystis sp. infection in several hosts in Brazil: a systematic review and meta-analysis

• Published in: Parasites & Vectors 2020, Vol.13 (1)
• Main Authors: Zanetti, Andernice dos Santos, Malheiros, Antonio Francisco, de Matos, Tatiane Amorim, Longhi, Fabiana Gulin, Moreira, Luciana Melhorança, Silva, Samuel Laudelino, Castrillon, Solange Kimie Ikeda, Ferreira, Silvana Margarida Benevides, Ignotti, Eliane, Espinosa, Omar Ariel
• Format: Report
• Language: English
• Subjects: Biodiversity; Birds; Causes of; Epidemics; Genetic research; Hemodialysis; Heterokonts; Host-parasite relationships; Identification and classification; Immunocompromised host; Immunotherapy; Infection; Medical research; Methods; Parasitic diseases; Phylogeny; Prevalence studies (Epidemiology); Wildlife
• ISSN: 1756-3305; 1756-3305
• DOI: 10.1186/s13071-020-3900-2

Blastocystis sp. affects a wide variety of animals and is the most common protozoan in human fecal samples with potential pandemic distribution. In the present study, a systematic review and meta-analysis were conducted to determine the prevalence and distribution of Blastocystis sp. in different classes of hosts in Brazil. Studies that analyzed hosts of various classes, including humans, domestic animals, wild animals or captive animals, were considered. The pooled prevalence of Blastocystis sp. infection was estimated by random effects models. For humans, similar prevalence rates were found for males (31.0%, 95% CI: 17.0-45.0%; weight 10%) and females (28.0%, 95% CI: 16.0-41.0%; weight 10%); the state of Mato Grosso do Sul showed the highest prevalence, with 41.0% positivity (95% CI: 36.0-46.0%; weight 2.9%). The prevalence among immunocompromised patients was 5.0% (95% CI: 3.0-7.0%; weight 10%), and the most common cause of immunosuppression was hemodialysis, with 23.0% (95% CI: 17.0-29.0%; weight 12.4%). Among classifications according to interaction with humans, wild and domestic animals presented values of 19.0% (95% CI: 7.0-31.0%; weight 42.6%) and 17.0% (95% CI: 13.0-21.0%; weight 29.6%), respectively. Among these animals, mammals (39.0%, 95% CI: 21.0-56.0%; weight 47.3%) and birds (18.0%, 95% CI: 10.0-27.0%; weight 39.3%) exhibited the highest prevalence. Phylogenetic analysis of Blastocystis sp. revealed greater genetic diversity for clades of subtypes (STs) ST1, ST2 and ST3. The overall prevalence of Blastocystis sp. in the Brazilian human population was 24%, which reflects the reality in the South, Southeast and Midwest regions, where prevalence rates of up to 40% were found. Among animals, mammals and birds exhibited the highest prevalence.