Role of Vitamin-D Receptor

Recent literature data have highlighted the important role of hypovitaminosis D in pregnancy complications and prenatal/perinatal health. Vitamin D action takes place through vitamin D receptor (VDR) activation. Two single nucleotide polymorphisms of VDR gene, FokI and BsmI, have been reported to af...

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Bibliographic Details
Published in:PloS one 2020-11, Vol.15 (11), p.e0239407
Main Authors: Caccamo, Daniela, Cannata, Attilio, Ricca, Sergio, Catalano, Liliana Maria, Montalto, Antonella Federica, Alibrandi, Angela, Ercoli, Alfredo, Granese, Roberta
Format: Article
Language:English
Subjects:
Development and progression
Diagnosis
Gestational hypertension
Health aspects
Risk factors
Single nucleotide polymorphisms
Vitamin D
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Summary:Recent literature data have highlighted the important role of hypovitaminosis D in pregnancy complications and prenatal/perinatal health. Vitamin D action takes place through vitamin D receptor (VDR) activation. Two single nucleotide polymorphisms of VDR gene, FokI and BsmI, have been reported to affect VDR molecular signaling and be associated with several disorders, including hypertension. We carried out a case-control study aimed to assess vitamin D serum levels together with the distribution of VDR FokI and BsmI in a population of 116 pregnant women with gestational hypertension (GH) and 69 normotensive pregnant women (CTR). Hypovitaminosis D was largely prevalent both in GH (81%) and CTR (69%) pregnant women. Vitamin D insufficiency (10-30 ng/ml) had a similar frequency in both cohorts (GH 60% vs CTR 58%), while vitamin D deficiency (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0239407