Tumor necrosis factor

Several single-nucleotide polymorphisms (SNPs) in the promoter region of the TNF-[alpha] gene can cause variations in the gene regulatory sites and act as risk factors for some autoimmune disorders as alopecia areata (AA) and vitiligo. This study aimed to detect the serum TNF-[alpha] (sTNF) level (b...

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Bibliographic Details
Published in:PloS one 2020-12, Vol.15 (12), p.e0240221
Main Authors: Abd El-Raheem, Talal, Mahmoud, Rania H, Hefzy, Enas M, Masoud, Mohamed, Ismail, Reham, Aboraia, Nesreen M. M
Format: Article
Language:English
Subjects:
Alopecia
Baldness
Genetic aspects
Genetic polymorphisms
Health aspects
Tumor necrosis factor
Vitiligo
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Summary:Several single-nucleotide polymorphisms (SNPs) in the promoter region of the TNF-[alpha] gene can cause variations in the gene regulatory sites and act as risk factors for some autoimmune disorders as alopecia areata (AA) and vitiligo. This study aimed to detect the serum TNF-[alpha] (sTNF) level (by ELISA) and the rs1800629 (by real-time PCR) among AA and vitiligo Egyptian patients and to determine their relation with disease duration and severity. In silico analysis of this SNP to study the molecular regulation of the mutant genotypes was also done. In AA patients, no risk was associated with the mutant genotypes vs. the normal genotype, or with A allele vs. G allele. The risk of vitiligo was significantly higher with the G/A and A/A genotypes compared with HCs (p = 0.011). Similarly, a significantly increased risk was noted in patients with A allele vs. G allele (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0240221