Potential value of urine lateral-flow lipoarabinomannan

Tuberculosis (TB) is a serious co-morbidity among children with severe acute malnutrition (SAM) and TB diagnosis remains particularly challenging in the very young. We explored whether, in a low HIV-prevalence setting, the detection of mycobacterial lipoarabinomannan (LAM) antigen in urine may assis...

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Bibliographic Details
Published in:PloS one 2021-05, Vol.16 (5), p.e0250933
Main Authors: Schramm, Birgit, Nganaboy, Rodrigue C, Uwiragiye, Piex, Mukeba, Didier, Abdoubara, Aboubacar, Abdou, Illa, Nshimiymana, Jean-Claude, Sounna, Seyni, Hiffler, Laurent, Flevaud, Laurence, Huerga, Helena
Format: Article
Language:English
Subjects:
Children
Diagnosis
Diseases
Health aspects
Malnutrition in children
Tuberculosis
Online Access:Get full text
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Summary:Tuberculosis (TB) is a serious co-morbidity among children with severe acute malnutrition (SAM) and TB diagnosis remains particularly challenging in the very young. We explored whether, in a low HIV-prevalence setting, the detection of mycobacterial lipoarabinomannan (LAM) antigen in urine may assist TB diagnosis in SAM children, a pediatric population currently not included in LAM-testing recommendations. To that end, we assessed LAM test-positivity among SAM children with and without signs or symptoms of TB. A cross-sectional assessment (February 2016-August 2017) included children
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0250933