Potentiating the antitumour response of CD8.sup.+ T cells by modulating cholesterol metabolism

Modulating cholesterol metabolism can improve CD8.sup.+ T-cell-mediated immunity against tumours; genetic or pharmacological inhibition of the cholesterol esterification enzyme ACAT1 led to higher plasma membrane cholesterol levels, better T-cell receptor clustering and signalling, improved immunolo...

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Bibliographic Details
Published in:Nature 2016, Vol.531 (7596), p.651
Main Authors: Yang, Wei, Bai, Yibing, Xiong, Ying, Zhang, Jin, Chen, Shuokai, Zheng, Xiaojun, Meng, Xiangbo, Li, Lunyi, Wang, Jing, Xu, Chenguang, Yan, Chengsong, Wang, Lijuan, Chang, Catharine C.Y, Chang, Ta-Yuan, Zhang, Ti, Zhou, Penghui, Song, Bao-Liang
Format: Report
Language:English
Subjects:
Care and treatment
Cholesterol metabolism
Health aspects
T cells
Tumors
Online Access:Get full text
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Summary:Modulating cholesterol metabolism can improve CD8.sup.+ T-cell-mediated immunity against tumours; genetic or pharmacological inhibition of the cholesterol esterification enzyme ACAT1 led to higher plasma membrane cholesterol levels, better T-cell receptor clustering and signalling, improved immunological synapse maturation, and enhanced antitumour activity in mice.
ISSN:0028-0836
DOI:10.1038/nature17412