Platelet surface receptor glycoprotein VI-dimer is overexpressed in stroke: The Glycoprotein VI in Stroke

Platelet activation underpins thrombus formation in ischemic stroke. The active, dimeric form of platelet receptor glycoprotein (GP) VI plays key roles by binding platelet ligands collagen and fibrin, leading to platelet activation. We investigated whether patients presenting with stroke expressed m...

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Bibliographic Details
Published in:PloS one 2022-01, Vol.17 (1), p.e0262695
Main Authors: Induruwa, Isuru, McKinney, Harriet, Kempster, Carly, Thomas, Patrick, Batista, Joana, Malcor, Jean-Daniel, Bonna, Arkadiusz, McGee, Joanne, Bumanlag-Amis, Elaine, Rehnstrom, Karola, Ashford, Sophie, Soejima, Kenji, Ouwehand, Willem, Farndale, Richard, Downes, Kate, Warburton, Elizabeth, Moroi, Masaaki, Jung, Stephanie
Format: Article
Language:English
Subjects:
Activation
Blood platelets
Development and progression
Glycoproteins
Health aspects
Physiological aspects
Stroke (Disease)
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Summary:Platelet activation underpins thrombus formation in ischemic stroke. The active, dimeric form of platelet receptor glycoprotein (GP) VI plays key roles by binding platelet ligands collagen and fibrin, leading to platelet activation. We investigated whether patients presenting with stroke expressed more GPVI on their platelet surface and had more active circulating platelets as measured by platelet P-selectin exposure. 129 ischemic or hemorrhagic stroke patients were recruited within 8h of symptom onset. Whole blood was analyzed for platelet-surface expression of total GPVI, GPVI-dimer, and P-selectin by flow cytometry at admission and day-90 post-stroke. Results were compared against a healthy control population (n = 301). The platelets of stroke patients expressed significantly higher total GPVI and GPVI-dimer (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0262695