Clinical usefulness of the pattern of non-adherence to anti-platelet regimen in stented patients

The Patterns of non-Adherence to Anti-Platelet Regimen in Stented Patients (PARIS) thrombotic risk score has been proposed to estimate the risk of stent thrombotic events after percutaneous coronary intervention (PCI). However, the prognostic value of the PARIS thrombotic risk score for long term al...

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Published in:PloS one 2022-09, Vol.17 (9), p.e0274287
Main Authors: Akama, Joh, Shimizu, Takeshi, Ando, Takuya, Anzai, Fumiya, Muto, Yuuki, Kimishima, Yusuke, Kiko, Takatoyo, Yoshihisa, Akiomi, Yamaki, Takayoshi, Kunii, Hiroyuki, Nakazato, Kazuhiko, Ishida, Takafumi, Takeishi, Yasuchika
Format: Article
Language:English
Subjects:
Care and treatment
Complications and side effects
Evaluation
Heart failure
Patient compliance
Patient outcomes
Stent (Surgery)
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Summary:The Patterns of non-Adherence to Anti-Platelet Regimen in Stented Patients (PARIS) thrombotic risk score has been proposed to estimate the risk of stent thrombotic events after percutaneous coronary intervention (PCI). However, the prognostic value of the PARIS thrombotic risk score for long term all-cause and cardiac mortalities, as well as hospitalization due to heart failure, has not yet been evaluated. Therefore, the aim of the present study was to evaluate the prognostic value of the PARIS thrombotic risk score for all-cause and cardiac mortalities and hospitalization due to heart failure following PCI. Consecutive 1,061 patients who underwent PCI were divided into three groups based on PARIS thrombotic risk score; low- (n = 320), intermediate- (n = 469) and high-risk (n = 272) groups. We followed up on all three groups for all-cause mortality, cardiac mortality and hospitalization due to heart failure. Kaplan-Meier analysis showed that all outcomes were highest in the high-risk group (P < 0.001, P = 0.022 and P < 0.001, respectively). Multivariate Cox proportional hazard analysis, adjusted for confounding factors, showed that the risk of all-cause mortality and hospitalization due to heart failure of the high-risk group were higher than those of the low-risk group (hazard ratios 1.76 and 2.14, P = 0.005 and P = 0.017, respectively). The PARIS thrombotic risk score is a significant prognostic indicator for all-cause mortality and hospitalization due to heart failure in patients after PCI.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0274287