Guanidinoacetic acid provides superior cardioprotection to its combined use with betaine and

This study aimed to determine how guanidinoacetic acid (GAA) or its combined administration with betaine (B) or creatine (C) influences the cardiac function, morphometric parameters, and redox status of rats subjected to high-intensity interval training (HIIT). This research was conducted on male Wi...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2022-08, Vol.100 (8), p.772
Main Authors: Prokic, Veljko Z, Rankovic, Marina R, Draginic, Nevena D, Andjic, Marijana M, Sretenovic, Jasmina Z, Zivkovic, Vladimir I, Jeremic, Jovana N, Milinkovic, Milica V, Bolevich, Sergey, Jakovljevic, Vladimir L.J, Pantovic, Suzana B
Format: Article
Language:English
Subjects:
Cardiac glycosides
Cardiotonic agents
Creatine
Dosage and administration
Drug therapy, Combination
Exercise
Guanidine
Health aspects
Methods
Testing
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Summary:This study aimed to determine how guanidinoacetic acid (GAA) or its combined administration with betaine (B) or creatine (C) influences the cardiac function, morphometric parameters, and redox status of rats subjected to high-intensity interval training (HIIT). This research was conducted on male Wistar albino rats exposed to HIIT for 4 weeks. The animals were randomly divided into five groups: HIIT, HIIT + GAA, HIIT + GAA + C, HIIT + GAA + B, and HIIT + GAA + C + B. After completing the training protocol, GAA (300 mg/kg), C (280 mg/kg), and B (300 mg/kg) were applied daily per os for 4 weeks. GAA supplementation in combination with HIIT significantly decreased the level of both systemic and cardiac prooxidants ([O.sup.-.sub.2], [H.sub.2][O.sub.2], N[O.sup.-.sub.2], and thiobarbituric acid reactive substances) compared with nontreated HIIT (p < 0.05). Also, GAA treatment led to an increase in glutathione and superoxide dismutase levels. None of the treatment regimens altered cardiac function. A larger degree of cardiomyocyte hypertrophy was observed in the HIIT + GAA group, which was reflected through an increase of the crosssectional area of 27% (p < 0.05) and that of the left ventricle wall thickness of 27% (p < 0.05). Since we showed that GAA in combination with HIIT may ameliorate oxidative stress and does not alter cardiac function, the present study is a basis for future research exploring the mechanisms of cardioprotection induced by this supplement in an HIIT scenario.
ISSN:0008-4212
DOI:10.1139/cjpp-2021-0801