Immunomodulatory drug fingolimod

Fingolimod (FTY720) is a drug derived from the fungicidal compound myriocin. As it was unclear whether FTY720 has antifungal effects as well, we aimed to characterize its effect on Candida albicans in vitro and in a mouse candidiasis model. First, antifungal susceptibility testing was performed in v...

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Bibliographic Details
Published in:PloS one 2022-12, Vol.17 (12), p.e0278488
Main Authors: Najarzadegan, Niloofar, Madani, Mahboobeh, Etemadifar, Masoud, Sedaghat, Nahad
Format: Article
Language:English
Subjects:
Analysis
Biological response modifiers
Candida albicans
Complications and side effects
Fingolimod
Health aspects
Patient outcomes
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Summary:Fingolimod (FTY720) is a drug derived from the fungicidal compound myriocin. As it was unclear whether FTY720 has antifungal effects as well, we aimed to characterize its effect on Candida albicans in vitro and in a mouse candidiasis model. First, antifungal susceptibility testing was performed in vitro. Then, a randomized, six-arm, parallel, open-label trial was conducted on 48 mice receiving oral FTY720 (0.3 mg/kg/day), intraperitoneal C. albicans inoculation, or placebo with different combinations and chorological patterns. The outcome measures of the trial included serum concentrations of interleukin-10 and interferon-gamma, absolute lymphocyte counts, and fungal burden values in the mice's livers, kidneys, and vaginas. Broth microdilution assay revealed FTY720's minimum inhibitory concentration (MIC.sub.99) to be 0.25 mg/mL for C. albicans. The infected mice treated with FTY720 showed lower fungal burden values than the ones not treated with FTY720 (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0278488