ALPHA-1 ANTITRYPSIN

Human plasma contains a number of proteinase inhibitors which together form 10% of the total plasma proteins. They control a number of functions such as fibrinolysis, coagulation, complement activation, connective tissue turnover and inflammatory reactions. Alpha-1 antitrypsin ([alpha]1-ATT), a seri...

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Bibliographic Details
Published in:Indian journal of clinical biochemistry 2022-05, Vol.27 (S1), p.S61
Main Authors: Salman, Khushtar Anwar, Ahmed, Sharique, Khan, Humera, Ehsan, Akif
Format: Article
Language:English
Subjects:
Blood proteins
Bronchitis
Liver
Proteases
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Summary:Human plasma contains a number of proteinase inhibitors which together form 10% of the total plasma proteins. They control a number of functions such as fibrinolysis, coagulation, complement activation, connective tissue turnover and inflammatory reactions. Alpha-1 antitrypsin ([alpha]1-ATT), a serine proteinase inhibitor (SERPIN) is found in highest concentration in plasma. [alpha]1-ATT (anti-protease), normally inhibits elastase (protease) released during phagocytosis by neutrophils present in alveoli of lungs The protein alpha-1 antitrypsin is a 52 kDa molecule produced primarily in hepatocytes and released into the blood circulation by the liver. The protein is present in all body tissues but appears to have its primary physiologic significance in the lungs, where it protects the healthy but fragile alveolar tissue from proteolytic damage by enzymes like neutrophil elastase. Alpha-1 antitrypsin is an acute phase protein which means that production by the liver is subject to various stimuli, including inflammatory mediators Therefore, protein levels in the circulation may vary depending on the medical condition of an individual. The normal serum concentration may range between 1.5 to 3.5 g/L (or 20 to. 48 [micro]M)
ISSN:0970-1915