Ocimum tenuiflorum extract

Ocimum tenuiflorum is a sacred medicinal plant bestowed with multiple health benefits. This plant is traditionally considered an adaptogen. Many scientific studies have indicated the anti-stress potential of Ocimum tenuiflorum but with higher doses. The present study investigated the effects of Holi...

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Bibliographic Details
Published in:PloS one 2023-05, Vol.18 (5), p.e0285012
Main Authors: C. M., Mohan Gowda, Murugan, Sasi Kumar, Bethapudi, Bharathi, Purusothaman, Divya, Mundkinajeddu, Deepak, D'Souza, Prashanth
Format: Article
Language:English
Subjects:
Analysis
Brain
Care and treatment
Complications and side effects
Corticosteroids
Diagnosis
Medicinal plants
Medicine, Botanic
Medicine, Herbal
Patient outcomes
Stress (Psychology)
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Summary:Ocimum tenuiflorum is a sacred medicinal plant bestowed with multiple health benefits. This plant is traditionally considered an adaptogen. Many scientific studies have indicated the anti-stress potential of Ocimum tenuiflorum but with higher doses. The present study investigated the effects of Holixer.sup.TM (a clinically studied standardized Ocimum tenuiflorum extract) on modulating stress using two in vivo models, namely the swim endurance study in mice and forced swim test in rats. In addition, we explored the mechanism of action of Holixer.sup.TM on the HPA axis using two in vitro cell-based assays to check for its inhibitory effect on cortisol release and CRF1 receptor antagonistic activity. Ocimum tenuiflorum extract enhanced the swimming time in mice, reduced the stress-induced increase in immobility time, and prevented the increase in corticosterone in rats subjected to the forced swim test. Further, Ocimum tenuiflorum extract inhibited cortisol release and exhibited a significant CRF1 receptor antagonist activity. Thus, Ocimum tenuiflorum extract was found effective in managing stress, and the effect could be due to the inhibition of cortisol release and the antagonistic effect on the CRF1 receptors.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0285012