Serum antibody levels to SARS-CoV-2 receptor-binding domain

Antibodies reactive with the SARS-CoV-2 receptor-binding domain (RBD) of the spike protein are associated with viral neutralization, however low antibody titers, specifically against SARS-CoV-2 variants, may result in reduced viral immunity post naturally acquired infection. A cohort study comprised...

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Bibliographic Details
Published in:PloS one 2023-11, Vol.18 (11), p.e0288713
Main Authors: Hau, Derrick, Pflughoeft, Kathryn J, Gates-Hollingsworth, Marcellene A, Kaur, Simranjit, Hill, Haydon J, Arias-Umana, Jose, Chung, Chelsea C, Smith, Valerie L, Riddle, Mark S, Healy, Sara A, AuCoin, David P
Format: Article
Language:English
Subjects:
Antibodies
Biological products
Enzyme-linked immunosorbent assay
Enzymes
Evaluation
Health aspects
Immunoassay
Infection
Medical colleges
Medical research
Medicine, Experimental
Vaccination
Viral antibodies
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Summary:Antibodies reactive with the SARS-CoV-2 receptor-binding domain (RBD) of the spike protein are associated with viral neutralization, however low antibody titers, specifically against SARS-CoV-2 variants, may result in reduced viral immunity post naturally acquired infection. A cohort study comprised of 121 convalescent individuals from northern Nevada was conducted looking at anti-RBD antibody levels by enzyme-linked immunosorbent assay. Serum was collected from volunteers by staff at the University of Nevada, Reno School of Medicine Clinical Research Center and assessed for antibodies reactive to various SARS-CoV-2 RBD domains relevant to the time of the study (2020-2021). A nonpaired group of vaccinated individuals were assessed in parallel. The goal of the study was to identify antibody levels against the RBD subunit in convalescent and vaccinated individuals from northern Nevada.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0288713