Readmission rates in HIV-associated burkitt lymphoma patients in the USA: a nationwide readmission database

• Published in: AIDS research and therapy 2023-11, Vol.20 (1)
• Main Authors: Tuin, Ashley M, Dort, Elizabeth J, Wieland, Clare M, Dilsaver, Danielle B, Velagapudi, Manasa
• Format: Article
• Language: English
• Subjects: Analysis; Antiviral agents; Burkitt's lymphoma; Care and treatment; Diagnosis; Dosage and administration; HIV patients; Hospital care; Medical care, Cost of; Prevention; Risk factors
• ISSN: 1742-6405; 1742-6405
• DOI: 10.1186/s12981-023-00575-3

Background People with human immunodeficiency virus have an increased risk of developing AIDS-defining malignancies including Burkitt lymphoma. Survival outcomes in HIV-associated Burkitt lymphoma remain worse than non-HIV-associated Burkitt lymphoma, despite widespread implementation of antiretroviral therapy. We aimed to determine the association between HIV status and risk for 30-day and 90-day readmission in the US after index hospitalization for Burkitt lymphoma. Methods Data were abstracted from the 2010-2020 Nationwide Readmissions Database; hospitalizations included patients with a primary BL diagnosis and were stratified by comorbid HIV. The primary outcome was all-cause readmission (30-day and 90-day). Secondary outcomes were in-hospital mortality, length of stay (LOS), and hospital cost. Between-HIV differences were evaluated via logistic and log-normal regression; multivariable models adjusted for comorbid kidney disease, hypertension, fluid and electrolyte disorders, and sepsis. Results Overall, there were 8,453 hospitalizations for BL and 6.0% carried an HIV diagnosis. Of BL hospitalizations, 68.4% were readmitted within 30-days post index BL hospitalization and 6.8% carried a HIV diagnosis. HIV-associated BL was associated with 43% higher adjusted odds of 30-day readmission (aOR 95% CI: 4% higher to 97% higher, p = 0.026). For 90-day readmission, 76.0% of BL patients were readmitted and 7.0% carried a HIV diagnosis. HIV-associated BL was not statistically associated with all-cause 90-day readmission (aOR 1.46, aOR 95% CI: 0% higher to 115% higher, p = 0.053). Conclusions HIV-positive status is associated with an increased risk for 30-day readmission after index hospitalization for Burkitt lymphoma. Keywords: Burkitt Lymphoma, HIV, Antiretroviral therapy, Hospital readmission, NRD, HIV associated Burkitt Lymphoma, Lymphoma