Zinc-α2-glycoprotein is involved in regulation of body weight through inhibition of lipogenic enzymes in adipose tissue

Context: Zinc-α2-glycoprotein (ZAG) was found to influence lipolysis in adipose tissue and has recently been proposed as a candidate factor in the regulation of body weight. Objective: To elucidate the association of serum ZAG level with body weight and percentage of body fat in normal, obese subjec...

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Bibliographic Details
Published in:International Journal of Obesity 2009-09, Vol.33 (9), p.1023-1030
Main Authors: Gong, F.Y, Zhang, S.J, Deng, J.Y, Zhu, H.J, Pan, H, Li, N.S, Shi, Y.F
Format: Article
Language:English
Subjects:
adipose tissue
Adipose tissues
animal models
Biological and medical sciences
body fat
Body weight
Control
Enzyme kinetics
Epidemiology
Fundamental and applied biological sciences. Psychology
Glycoproteins
Health Promotion and Disease Prevention
high fat diet
humans
Internal Medicine
lipolysis
liposome transfection
Measurement
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
mice
Obesity
original-article
Properties
Public Health
Vertebrates: endocrinology
weight control
zinc
zinc-alpha2-glycoprotein
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Summary:Context: Zinc-α2-glycoprotein (ZAG) was found to influence lipolysis in adipose tissue and has recently been proposed as a candidate factor in the regulation of body weight. Objective: To elucidate the association of serum ZAG level with body weight and percentage of body fat in normal, obese subjects and high-fat diet (HFD)-induced obese mice. Design: The relationship between serum ZAG and obesity-related parameters was studied in 44 human subjects and 36 mice fed standard food and HFD. Furthermore, the effects of ZAG overexpression on adipose tissue of mice was also evaluated by using a liposome transfection method. Results: Serum ZAG level was significantly lower in obese patients and obese mice in comparison to that in people and mice with normal weight. The further statistical analysis demonstrated that ZAG level was negatively correlated with body weight (r=-0.62, P
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2009.141