Total intravenous anesthesia using propofol or propofol/ketamine in bitches undergoing ovariohysterectomy/Anestesia intravenosa total utilizando propofol ou propofol/cetamina em candelas submetidas a ovariossalpingohisterectomia

• Published in: Ciência rural 2009-08, Vol.39 (5), p.1438
• Main Authors: Gasparini, Simone Salata, Luna, Pacca Stelio Loureiro, Cassu, Renata Navarro, de Biasi, Fernando
• Format: Article
• Language: Spanish
• ISSN: 0103-8478

This study aimed to investigate the cardiopulmonary and analgesic effects of propofol and propofol/ketamine infusion in bitches premedicated with atropine and xylazine and submitted to ovariohisterectomy. In six bitches, anesthesia was induced by 5mg [kg.sup.-1]of propofol and maintained initially with 0.4mg [kg.sup.-1].[min.sup.-1] of propofol (GP). In the other six bitches, anesthesia was induced with a combination of 3.5mg [kg.sup.-1] propofol and 1mg [kg.sup.-1] of ketamine and maintained initially with 0.28mg [kg.sup.-1].[min.sup.-1] propofol and 0.06mg [kg.sup.-1].[min.sup.-1] of ketamine (GPK). Heart and respiratory rates, arterial blood pressure, minute ventilation, end tidal C[O.sub.2], pulse hemoglobin [O.sub.2] saturation, blood gas analysis, plasma glucose concentration and temperature were measured before and every 10 minutes during anesthesia. Mean arterial blood pressure reduced from 20 to 40 minutes of propofol anesthesia. Temperature reduction and hypercapnia with respiratory acidosis occurred in both groups during anesthesia. Pa[O.sub.2], bicarbonate and glucose increased only during propofol/ ketamine anesthesia. Propofol infusion rate was increased by 50 and 20% during anesthesia in GP and GPK respectively to allow satisfactory surgical anesthesia. Both anesthetic protocols were safe and adequate for ovariohysterectomy in bitches, considering that controlled ventilation is performed when necessary and propofol infusion rate is adjusted to 0,.6 and 0.34mg [kg.sup.-1].[min.sup.-1] in GP and GPK according to the surgical stimulus. Key words: infusion, general anaesthetic, dissociative anaesthetic. Objetivou-se avaliar os efeitos cardiorrespiratorio e analgesico da infusao continua com propofol e propofol/cetamina em cadelas pre-medicadas com atropina e xilazina, submetidas a ovariossalpingohisterectomia (OSH). Em seis cadelas (GP) a inducao anestesica foi realizada com propofol (5mg [kg.sup.-1] iv), seguido da manutencao anestesica com o mesmo farmaco em infusao continua intravenosa na taxa inicial de 0,4mg [kg.sup.-1].[min.sup.-1]. Outras seis cadelas (GPC) receberam a associacao de propofol (3,5mg [kg.sup.-1] iv) e cetamina (1mg [kg.sup.-1] iv) como inducao anestesica. Depois, foi feita manutencao anestesica em infusao continua intravenosa inicial com 0,28mg [kg.sup.-1].[min.sup.-1] e 0,06mg [kg.sup.-1].[min.sup.-1] de propofol e cetamina, respectivamente. Os seguintes parametros foram mensurados durante a anestesia a cada 10 minutos: fr