Effects of ovariectomy and resistance training on lipid content in skeletal muscle, liver, and heart; fat depots; and lipid profile

• Published in: Applied physiology, nutrition, and metabolism nutrition, and metabolism, 2009-12, Vol.34 (6), p.1079-1086
• Main Authors: Leite, Richard Diego, Prestes, Jonato, Bernardes, Celene Fernandes, Shiguemoto, Gilberto Eiji, Pereira, Guilherme Borges, Duarte, Josiane Oliveira, Domingos, Mateus Moraes, Baldissera, Vilmar, de Andrade Perez, Sérgio Eduardo
• Format: Article
• Language: English
• Subjects: Abdominal Fat - chemistry; Animals; Biological and medical sciences; Cardiovascular Diseases - prevention & control; contenu lipidique tissulaire; entraînement à la force; fat depots; Female; Fundamental and applied biological sciences. Psychology; Health aspects; Heart; lipid profile; Lipids; Lipids - analysis; Lipids - blood; Lipoproteins - blood; Liver; Liver - chemistry; Muscle, Skeletal - chemistry; Muscles; Musculoskeletal system; Myocardium - chemistry; ovariectomie; Ovariectomy; Physiological aspects; profil lipidique; Random Allocation; Rats; Rats, Wistar; Resistance Training; Risk Factors; réserves de graisses; tissues lipid content; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports; Weight training
• ISSN: 1715-5312; 1715-5320
• DOI: 10.1139/H09-116

The aim of the present study was to investigate the effects of resistance training on skeletal muscle lipid content, liver lipid content, heart lipid content, fat depots, and lipid profile in ovariectomized rats. Wistar adult female rats were divided into 4 groups (n = 10 per group): sedentary (Sed-Intact), sedentary ovariectomized (Sed-Ovx), strength trained (ChronicEx-intact), and strength trained ovariectomized (ChronicEx-Ovx). A 12-week strength-training period was used, during which the animals climbed a 1.1-m vertical ladder with weights attached to their tails. The sessions were performed once every 3 days, with 4-9 climbs and 8-12 dynamic movements per climb. Ovariectomy increased liver lipid content and fat depots, and heart and muscle lipid content. There was an increase in the atherogenic index and a negative change in lipid profile because of the ovariectomy. Resistance training decreased lipid content in the liver, soleus, and tibialis anterior, decreased fat depots (mesenteric and retroperitoneal), and changed the lipid profile, independently of ovarian hormone status. These results indicate the potential benefits of resistance training as an alternative strategy to control the effects of ovariectomy on fat depot, lipid profile, and tissue lipid content.