Clinicopathological features in patients with rare ovarian cancers/Nadir gorulen over tumorlerinde klinikopatolojik ozellikler

• Published in: Türk onkoloji dergisi 2012-03, Vol.27 (1), p.1
• Main Authors: Bilici, Ahmet, Oven Ustaalioglu, Basak Bala, Seker, Mesut, Gumus, Mahmut, Unal, Orhan
• Format: Article
• Language: Turkish
• ISSN: 1300-7467
• DOI: 10.5505/tjoncol.2012.627

OBJECTIVES In this study, it was aimed to clarify the features of patients with rare ovarian cancers (ROC) and to determine the prognostic factors associated with survival. METHODS A total of 48 patients with ROC, seen between 2003 and 2011, were analyzed retrospectively. RESULTS There were 12 (25%) germ-cell tumors (GCT), 25 (52.1%) sex cord-stromal tumors (SCT) and 11 (29.1%) "other" ROC patients. Significant differences were detected with respect to age, tumor localization, initial symptom(s) at diagnosis, surgery type, tumor size, and tumor grade. GCTs were commonly localized in the left and/or bilateral ovaries, while SCT and the other ROCs were frequently localized in the right ovary (p = 0.02). Staging at primary surgery was high in the other ROCs compared with GCTs and SCTs (p = 0.02). Patients with GCT were younger in age (p = 0.006) and had larger (p = 0.03) and well-differentiated (p = 0.01) tumors than those with SCTs or the other ROCs. Survivals were similar among groups. CONCLUSION ROCs should be evaluated separately from epithelial ovarian cancers because of their different biological features and different natural history. Key words: Rare ovarian cancers; overall survival; progression-free survival; clinicopathological factors. AMAC Bu calismada nadir gorulen over kanserli (NGOK) hastalarin klinikopatolojik ozellikleri ile sagkalim uzerine etkili prognostik faktorlerin ortaya konulmasi amaclanmistir. GEREC VE YONTEM 2003 ile 2011 tarihleri arasinda takip ve tedavi edilen 48 NGOK'li hasta geriye donuk olarak analiz edildi. BULGULAR Hastalarin 12'si (%25) germ hucreli tumorlu (GHT), 25'i (%52.1) seks-kord stromal tumorlu (SKT) ve 11'i (%29.1) diger NGOK'li idi. Yas, tumor yerlesimi, basvuru yakinmasi, cerrahi tipi, tumor capi ve tumor grade'i yonunden gruplar arasinda anlamli farklilik saptandi. GHT'li hastalar daha cok sol overde ya da bilateral olma egilimindeyken, SKT'li ve diger NGOK'li hastalar sag over lokalizasyonlu olma egilimindeydiler (p = 0.02). GHT ve SKT'li hastalara gore diger NGOK'li hastalarda tam evreleme cerrahisi daha fazla uygulanmisti (p = 0.02). GHT'ler diger iki gruba gore anlamli olarak daha genc yasta gorulmekte (p = 0.006) ve daha buyuk tumor capli (p=0.03) ve iyi diferansiye olma egimlindeydiler (p = 0.01). Gruplar arasinda sagkalimlar benzerdi. SONUC NGOK'ler farkli biyolojik ozellikleri ve farkli klinik gidisleri nedeniyle epitelyal over kanserlerinden farkli degerlendirilmelidir. Anahtar sozcukler: Nadir over kan