Improved method for the synthesis of 1-vinylindole

A highly efficient method has been developed for the synthesis of 1-vinylindole based on the vinylation of indole by acetylene at atmospheric pressure using the superbase KOH–DMSO catalytic system. The method allows the preparation of the 1-vinylindole in 94% yield with a purity of 99% (after a sing...

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Bibliographic Details
Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2013-06, Vol.49 (3), p.404-407
Main Authors: Shmidt, E. Yu, Protsuk, N. I., Vasil’tsov, A. M., Ivanov, A. V., Mikhaleva, A. I., Trofimov, B. A.
Format: Article
Language:English
Subjects:
Acetylene
Chemistry
Chemistry and Materials Science
Methods
Organic Chemistry
Organic conductors
Pharmacy
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Summary:A highly efficient method has been developed for the synthesis of 1-vinylindole based on the vinylation of indole by acetylene at atmospheric pressure using the superbase KOH–DMSO catalytic system. The method allows the preparation of the 1-vinylindole in 94% yield with a purity of 99% (after a single distillation of the crude product).
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-013-1260-y