First spin-labeled cytisine derivatives

Spin-labeled cytisine derivatives containing stable pyrrolidine and piperidine nitroxyl radicals were synthesized by acylation and alkylation of the secondary amine. Toxicological studies showed that introduction of the nitroxyl group decreased significantly the general toxicity.

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Bibliographic Details
Published in:Chemistry of natural compounds 2013-05, Vol.49 (2), p.311-315
Main Authors: Polienko, Yu. F., Vinogradova, V. I., Sagdullaev, Sh. Sh, Abdullaev, N. D., Gatilov, Yu. V., Grigor′ev, I. A.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacy
Plant Sciences
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Description
Summary:Spin-labeled cytisine derivatives containing stable pyrrolidine and piperidine nitroxyl radicals were synthesized by acylation and alkylation of the secondary amine. Toxicological studies showed that introduction of the nitroxyl group decreased significantly the general toxicity.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-013-0588-y