Synthesis of 3-alkoxycarbonyl-6-alkylsulfanyl-4-[2-(difluoromethoxy)phenyl]-1,4-dihydropyridines and related derivatives as analogs of cognition enhancer cerebrocrast

4-[2-(Difluoromethoxy)phenyl]-substituted 3-alkoxycarbonyl-6-alkylsulfanyl-3-cyano-2-methyl-1,4-di-hydropyridines and related pyridine and 4,7-dihydrothieno[2,3- b ]pyridine derivatives have been prepared, their memory-improving activity has been studied using the passive avoidance responses in the...

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Published in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2013-07, Vol.49 (4), p.566-573
Main Authors: Krauze, A., Andzans, Z., Krasnova, L., Germane, S., Domracheva, I., Adlere, I., Grinberga, S., Duburs, G.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Cognition
Nitriles
Organic Chemistry
Pharmacy
Pyridine
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Summary:4-[2-(Difluoromethoxy)phenyl]-substituted 3-alkoxycarbonyl-6-alkylsulfanyl-3-cyano-2-methyl-1,4-di-hydropyridines and related pyridine and 4,7-dihydrothieno[2,3- b ]pyridine derivatives have been prepared, their memory-improving activity has been studied using the passive avoidance responses in the acquisition test, and their calcium overload-preventing activity in SH-SY5Y neuroblastoma cell line in the presence of the agonist carbachol has been examined. 1,4-Dihydropyridine derivatives bearing the 2-propoxyethoxycarbonyl group in position 3 and having weak influence on calcium overload in neuronal cells show high activity comparable with that of cerebrocrast.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-013-1283-4