Synthesis, radiochemistry and stability of the conjugates of technetium-99m complexes with Substance P

Two types of technetium-99m complexes: (i) with the Hynic ligand linked to Substance P(1–11) and (ii) of the type ‘4 + 1’ consisting of tetradentate tripodal chelator tris(2-mercaptoethyl)-amine and monodentate isocyanide ligand previously coupled with Substance P(1–11), have been prepared on the n....

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry 2013-11, Vol.298 (2), p.1171-1177
Main Authors: Gniazdowska, Ewa, Koźmiński, Przemysław, Fuks, Leon
Format: Article
Language:English
Subjects:
Amines
Chemistry
Chemistry and Materials Science
Diagnostic Radiology
Hadrons
Heavy Ions
Inorganic Chemistry
Nuclear Chemistry
Nuclear Physics
Physical Chemistry
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Summary:Two types of technetium-99m complexes: (i) with the Hynic ligand linked to Substance P(1–11) and (ii) of the type ‘4 + 1’ consisting of tetradentate tripodal chelator tris(2-mercaptoethyl)-amine and monodentate isocyanide ligand previously coupled with Substance P(1–11), have been prepared on the n.c.a. scale. The obtained conjugates exhibit different lipophilicity and high stability in neutral aqueous solutions, even in the presence of excess concentration of histidine/cysteine competitive standard ligands. The conjugate ( 99m Tc(NS 3 )(CN)) 2 –SP containing two technetium-99m species in the molecule may be expected to be an extremely good diagnostic radiopharmaceutical.
ISSN:0236-5731
1588-2780
DOI:10.1007/s10967-013-2526-7