Synthesis of isoquinoline alkaloid derivatives from eugenol

Alkylation under phase-transfer catalysis conditions (18-crown-6/KOH) of eugenol was used for cyclocondensation with nitriles (Ritter reaction), the products of which were isoquinoline derivatives.

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Bibliographic Details
Published in:Chemistry of natural compounds 2012-05, Vol.48 (2), p.285-287
Main Authors: Mikhailovskii, A. G., Surikova, O. V., Limanskii, E. S., Vakhrin, M. I.
Format: Article
Language:English
Subjects:
Alkaloids
Crown ethers
Medicine
Nitriles
Organic Chemistry
Pharmacy
Phenols
Plant Sciences
Resveratrol
Schiff bases
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Description
Summary:Alkylation under phase-transfer catalysis conditions (18-crown-6/KOH) of eugenol was used for cyclocondensation with nitriles (Ritter reaction), the products of which were isoquinoline derivatives.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-012-0222-4